6SEQ Chain A
Serine/threonine-protein kinase LMTK3 (LMTK3)
Inactive — 0.0%DFG-outαC-in
Resolution
2.1 Å
R-value
0.198
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms20
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLS
UniProt reference sequence
LSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTY
Aligned reference sequence
LSYL----------------QEIGSGW----------------FGKVILGEI--FSDY----------------------------------TPAQVVVKELR--ASAGPLE---------------------------QRKFISEAQPYRSL--------------------------QHPNVLQCLGLCVETL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLLIMEFCQL--------------GDLKRYLRA--QRPPEGLSPELP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRDLRTLQRMGLEIARGLAHLHSH---------------------------------------------NYVHSDL-----ALRNCLLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTVRIGDYGLAHSNYKEDYY--LTP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERLWIPLRWAAPELLGE--LHGTFMV-----------------------VDQS-RESNIWSLGVTLWELFEF--G--------------AQPYRH--------------------------------------------------LSDEEVLAFVVRQ--QHVKLARPRLKLPYA------------------------------------------------------------------------------------------------DYWYDILQSCWRP-PAQRPS--------------ASDLQLQLTY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSYL----------------QEIGSGW----------------FGKVILGEI--FSDY----------------------------------TPAQVVVKELR--ASAGPLE---------------------------QRKFISEAQPYRSL--------------------------QHPNVLQCLGLCVETL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFLLIMEFCQL--------------GDLKRYLRA--QRPP----PELP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRDLRTLQRMGLEIARGLAHLHSH---------------------------------------------NYVHSDL-----ALRNCLLTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTVRIGDYGLAHSNYKEDYY--LTP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERLWIPLRWAAPELLGE--LHG--MV-----------------------VDQS-RESNIWSLGVTLWELFEF--G--------------AQPYRH--------------------------------------------------LSDEEVLAFVVRQ--QHVKLARPRLKLPYA------------------------------------------------------------------------------------------------DYWYDILQSCWRP-PAQRPS--------------ASDLQLQLTY
Activation segment
DYGLAHSNYKEDYY--LTP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERLWIPLRWAAPE
Binding pocket
QEIGSGWFGKVILVVVKELKFISEAQPYRSLQPNVLQCLGLLLIMEFCQLGDLKRYLRAHLHSHNYVHSDLALRNCLLIGDYGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6SEQ, Chain A