6S73 Chain A
Serine/threonine-protein kinase Nek7 (NEK7)
Inactive — 0.4%DFG-inαC-inType1 · F9N
Resolution
3.5 Å
R-value
0.237
Predicted activity confidence0.4%
Structure info
Alternate conformation—
Missing atoms68
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
ALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLHKQLNHPNVIKFYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDFGLGRLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTA
UniProt reference sequence
FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKR
Aligned reference sequence
FRIE----------------KKIGRGQ----------------FSEVYRAAC--LL------------------------------------DGVPVALKKVQ--IFDLMDAKA-------------------------RADCIKEIDLLKQL--------------------------NHPNVIKYYASFIEDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELNIVLELADA--------------GDLSRMIKH--FKKQKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIPERTVWKYFVQLCSALEHMHSR---------------------------------------------RVMHRDI-----KPANVFITA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGVVKLGDLGLGRFFSSKTTA--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSLVGTPYYMSPERIHE--------------------------------NGYN-FKSDIWSLGCLLYEMAAL-----------------QSPFYG--DK----------------------------------------------MNLYSLCKKIEQC--DYPPLPSDHYS----------------------------------------------------------------------------------------------------EELRQLVNMCINPDPEKRPD--------------VTYVYDVAKR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FRIE----------------KKIGRGQ----------------FSEVYRAAC--LL------------------------------------DGVPVALKKVQ--IFDLMDAKA-------------------------RADCIKEIDLHKQL--------------------------NHPNVIKFYASFIEDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELNIVLELADA--------------GDLSRMIKH--FKKQKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIPERTVWKYFVQLCSALEHMHSR---------------------------------------------RVMHRDI-----KPANVFITA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGVVKLGDFGLGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVGTPYYMSPERIHE--------------------------------NGYN-FKSDIWSLGCLLYEMAAL-----------------QSPFYG--DK----------------------------------------------MNLYSLCKKIEQC--DYPPLPSDHYS----------------------------------------------------------------------------------------------------EELRQLVNMCINPDPEKRPD--------------VTYVYDVAKR
Activation segment
DFGLGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVGTPYYMSPE
Binding pocket
KKIGRGQFSEVYRVALKKVDCIKEIDLHKQLNPNVIKFYASNIVLELADAGDLSRMIKHHMHSRRVMHRDIKPANVFILGDFGLG
Ligand info
Orthosteric ligand
F9N
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6S73, Chain A