6S1J Chain A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Active — 74.2%DFG-inαC-inType1 · KRK
Resolution
1.41 Å
R-value
0.156
Predicted activity confidence74.2%
Structure info
Alternate conformationB
Missing atoms7
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
UniProt reference sequence
YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
Aligned reference sequence
YEID----------------SLIGKGS----------------FGQVVKAYD--RV------------------------------------EQEWVAIKIIK--NKKAF-----------------------------LNQAQIEVRLLELM--NKHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEMLS---------------YNLYDLLRN--TNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKFAQQMCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQYIQSRFYRSPEVLLG--------------------------------MPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------ANEVDQMNKIVEV--LGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADY--------------------------------------LKFKDLILRMLDYDPKTRIQ--------------PYYALQHSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------SLIGKGS----------------FGQVVKAYD--RV------------------------------------EQEWVAIKIIK--NKKAF-----------------------------LNQAQIEVRLLELM--NKHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEMLS---------------YNLYDLLRN--TNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKFAQQMCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPEVLLG--------------------------------MPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------ANEVDQMNKIVEV--LGIPPAHILDQAPKARKFFEKLPDGTWNLKK------EYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADY--------------------------------------LKFKDLILRMLDYDPKTRIQ--------------PYYALQHSFF
Activation segment
DFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPE
Binding pocket
SLIGKGSFGQVVKVAIKIIQAQIEVRLLELMNYYIVHLKRHCLVFEMLS_YNLYDLLRNATPELSIIHCDLKPENILLIVDFGSS
Ligand info
Orthosteric ligand
KRK
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6S1J, Chain A