6RUU Chain C
Interleukin-1 receptor-associated kinase 3 (IRAK3)
Inactive — 0.0%DFG-outαC-in
Resolution
2.95 Å
R-value
0.23
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms50
Missing residues11
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
VYRVELTYAVKLFCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAE
UniProt reference sequence
EGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES
Aligned reference sequence
EGT---RNFHKD--------FLIGEGE----------------IFEVYRVEI----------------------------------------QNLTYAVKLFK--QEKKMQCKKH------------------------WKRFLSELEVLLLF--------------------------HHPNILELAAYFTETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFCLIYPYMRN--------------GTLFDRLQC--VGDTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNV--QPC----------------------------------------SVICGSI-----SSANILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFQPKLTDFAMAHFRSHLEHQ--SCTINMT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSSKHLWYMPEEYIRQ--------------------------------GKLS-IKTDVYSFGIVIMEVLTG-----------------CRVVLD--DPKH--------------------------------------------IQLRDLLRELMEK--RGLDSCLSFLDKKVPPCPRNFS-----------------------------------------------------------------------------------------AKLFCLAGRCAATRAKLRPS--------------MDEVLNTLES
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
----------------------------------------------VYRVE-------------------------------------------LTYAVKLF---------CKKH------------------------WKRFLSELEVLLLF--------------------------HHPNILELAAYFTETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFCLIYPYMRN--------------GTLFDRLQC--VGDTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNV--QPC----------------------------------------SVICGSI-----SSANILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFQPKLTDFAM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KHLWYMPEEYIRQ--------------------------------GKLS-IKTDVYSFGIVIMEVLTG-----------------CRVVLD--DPKH--------------------------------------------IQLRDLLRELMEK--RGLDSCLSFLDKKVPPCPRNFS-----------------------------------------------------------------------------------------AKLFCLAGRCAATRAKLRPS--------------MDEVLNTLES
Activation segment
DFAM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KHLWYMPEE
Binding pocket
__________VYRYAVKLFRFLSELEVLLLFHPNILELAAYCLIYPYMRNGTLFDRLQCNVQPCSVICGSISSANILLLTDFAM_
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6RUU, Chain C