6RUU Chain A
Interleukin-1 receptor-associated kinase 3 (IRAK3)
Active — 50.6%DFG-inαC-in
Resolution
2.95 Å
R-value
0.23
Predicted activity confidence50.6%
Structure info
Alternate conformation—
Missing atoms14
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSSCTINMTHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASL
UniProt reference sequence
EGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES
Aligned reference sequence
EGT---RNFHKD--------FLIGEGE----------------IFEVYRVEI----------------------------------------QNLTYAVKLFK--QEKKMQCKKH------------------------WKRFLSELEVLLLF--------------------------HHPNILELAAYFTETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFCLIYPYMRN--------------GTLFDRLQC--VGDTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNV--QPC----------------------------------------SVICGSI-----SSANILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFQPKLTDFAMAHFRSHLEHQ--SCTINMT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSSKHLWYMPEEYIRQ--------------------------------GKLS-IKTDVYSFGIVIMEVLTG-----------------CRVVLD--DPKH--------------------------------------------IQLRDLLRELMEK--RGLDSCLSFLDKKVPPCPRNFS-----------------------------------------------------------------------------------------AKLFCLAGRCAATRAKLRPS--------------MDEVLNTLES
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
EGT---RNFHKD--------FLIGEGE----------------IFEVYRVEI----------------------------------------QNLTYAVKLFK--QE---QCKKH------------------------WKRFLSELEVLLLF--------------------------HHPNILELAAYFTETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFCLIYPYMRN--------------GTLFDRLQC--VGDTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNV--QPC----------------------------------------SVICGSI-----SSANILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFQPKLTDFAMAHFRS-------SCTINMT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLWYMPEEYIRQ--------------------------------GKLS-IKTDVYSFGIVIMEVLTG-----------------CRVVLD--DPKH--------------------------------------------IQLRDLLRELMEK--RGLDSCLSFLDKKVPPCPRNFS-----------------------------------------------------------------------------------------AKLFCLAGRCAATRAKLRPS--------------MDEVLNTLES
Activation segment
DFAMAHFRS-------SCTINMT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLWYMPEE
Binding pocket
FLIGEGEIFEVYRYAVKLFRFLSELEVLLLFHPNILELAAYCLIYPYMRNGTLFDRLQCNVQPCSVICGSISSANILLLTDFAMA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6RUU, Chain A