6RSR Chain A
Serine/threonine-protein kinase TBK1 (TBK1)
Inactive — 0.0%DFG-inαC-outType1 · KHT
Resolution
3.15 Å
R-value
0.282
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
AMGQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELGTEEYLHPDMYEGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQET
UniProt reference sequence
HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD
Aligned reference sequence
HLWL--LS------------DILGQGA----------------TANVFRGRH--KK------------------------------------TGDLFAIKVFN--NISFLRP---------------------------VDVQMREFEVLKKL--------------------------NHKNIVKLFAIEEETT--TR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKVLIMEFCPC--------------GSLYTVLEE--PSNAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPESEFLIVLRDVVGGMNHLREN---------------------------------------------GIVHRDI-----KPGNIMRVI--GEDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVYKLTDFGAARELEDDEQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLYGTEEYLHPDMYER--AVLRKDHQ----------------------KKYG-ATVDLWSIGVTFYHAATG-----------------SLPFRP--FEGPR-------------------------------------------RNKEVMYKIITGK--PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ------------------------------------------------------------------------------VLLTPVLANILEADQEKCWG--------------FDQFFAETSD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
HLWL--LS------------DILGQGA----------------TANVFRGRH--KK------------------------------------TGDLFAIKVFN--NISFLRP---------------------------VDVQMREFEVLKKL--------------------------NHKNIVKLFAIEEETT--TR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKVLIMEFCPC--------------GSLYTVLEE--PSNAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPESEFLIVLRDVVGGMNHLREN---------------------------------------------GIVHRDI-----KPGNIMRVI--GEDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVYKLTDFGAAREL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTEEYLHPDMYE------------------------------------G-ATVDLWSIGVTFYHAATG-----------------SLPFRP--FEGPR-------------------------------------------RNKEVMYKIITGK--PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ------------------------------------------------------------------------------VLLTPVLANILEADQEKCWG--------------FDQFFAETSD
Activation segment
DFGAAREL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTEEYLHPD
Binding pocket
DILGQGATANVFRFAIKVFVDVQMREFLKKLNKNIVKLFAIVLIMEFCPCGSLYTVLEPHLRENGIVHRDIKPGNIMRLTDFGAA
Ligand info
Orthosteric ligand
KHT
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6RSR, Chain A