6R5F Chain B
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
Inactive — 0.8%DFG-outαC-outType3 · JSW
Resolution
3.25 Å
R-value
0.245
Predicted activity confidence0.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues10
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
IKMKSSDFLVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
UniProt reference sequence
FLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRP
Aligned reference sequence
FLES----------------AELDSGG----------------FGKVSLCFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMCYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--NEEHNELREVDGTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKNGGTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------ICEQQLIMCIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
--------------------IKMKSSD----------------F-LVSLAFH--R-------------------------------------TQGLMIMKTVY--KGPNCIEH--------------------------NEALLEEAKMMNRL--------------------------RHSRVVKLLGVIIEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYSLVMEYMEK--------------GNLMHVLKA--EM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STPLSVKGRIILEIIEGMAYLHGK---------------------------------------------GVIHKDL-----KPENILVDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFHIKIADLGLASFKMWSKLN--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLYYMAPEHLND--VN----------------------------AKPT-EKSDVYSFAVVLWAIFAN-----------------KEPYEN--A-----------------------------------------------IAEQQLIMAIKSG--NRPDVDDITEYCP--------------------------------------------------------------------------------------------------REIISLMKLCWEANPEARPT--------------FPGIEEKFRP
Activation segment
DLGLASFKMWSKLN--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLYYMAPE
Binding pocket
__________VSLMIMKTVALLEEAKMMNRLRSRVVKLLGVSLVMEYMEKGNLMHVLKAYLHGKGVIHKDLKPENILVIADLGLA
Ligand info
Orthosteric ligand
JSW
Allosteric ligand
None
Ligand typeType3
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6R5F, Chain B