6QP5 Chain A
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
Inactive — 0.1%DFG-inαC-out
Resolution
1.9 Å
R-value
0.194
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms13
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
KKQAEDIKKIFEFKETLGTGSEVVLAEEKATGKLFAVKCIPKKALSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFA
UniProt reference sequence
FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI
Aligned reference sequence
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFGLSKMEGKGDVM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFK----------------ETLGTG------------------SEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKAL--------------------------------SIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Activation segment
DFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGYVAPE
Binding pocket
ETLGTG__SEVVLFAVKCISIENEIAVLRKIKENIVALEDIYLVMQLVSGGELFDRIVEYLHRMGIVHRDLKPENLLYISDFG__
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QP5, Chain A