6QFT Chain A
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Active — 57.1%DFG-inαC-inType1 · J0B
Resolution
2.7 Å
R-value
0.24
Predicted activity confidence57.1%
Structure info
Alternate conformation—
Missing atoms18
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
QTGYLTIGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRCAAYMAPERIDPRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK
UniProt reference sequence
LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
Aligned reference sequence
LENL----------------GEMGSGT----------------CGQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDFGISGRLVDSKAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSAGCAAYMAPERIDP--PDPTK-------------------------PDYD-IRADVWSLGISLVELATG-----------------QFPYKN--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LENL----------------GEMGSGT----------------CGQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDFGISGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAAYMAPERIDP--------------------------------------RADVWSLGISLVELATG-----------------QFPYKN--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Activation segment
DFGISGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAAYMAPE
Binding pocket
GEMGSGTCGQVWKIAVKQMRILMDLDVVLKSHPYIVQCFGTFIAMELMGTCAEKLKKRMLKEKHGVIHRDVKPSNILLLCDFGIS
Ligand info
Orthosteric ligand
J0B
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QFT, Chain A