6QF4 Chain A
Serine/threonine-protein kinase 17B (STK17B)
Active — 97.7%DFG-inαC-inATPlike · ADP
Resolution
2.49 Å
R-value
0.187
Predicted activity confidence97.7%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETS
UniProt reference sequence
YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWL
Aligned reference sequence
YILT--S-------------KELGRGK----------------FAVVRQCIS--KS------------------------------------TGQEYAAKFLK--KRRRGQDC--------------------------RAEILHEIAVLELA--K-----------------------SCPRVINLHEVYENTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIILILEYAAG--------------GEIFSLCLP--ELAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN---------------------------------------------NIVHLDL-----KPQNILLSS--IYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPEILNY--------------------------------DPIT-TATDMWNIGIIAYMLLTH-----------------TSPFVG--------------------------------------------------EDNQETYLNISQV--NVDYSEETFSSVS--------------------------------------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT--------------AEICLSHSWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YILT--S-------------KELGRGK----------------FAVVRQCIS--KS------------------------------------TGQEYAAKFLK--KRRRGQDC--------------------------RAEILHEIAVLELA--K-----------------------SCPRVINLHEVYENTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIILILEYAAG--------------GEIFSLCLP--ELAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN---------------------------------------------NIVHLDL-----KPQNILLSS--IYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGMSRKIGHAC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMGTPEYLAPEILNY--------------------------------DPIT-TATDMWNIGIIAYMLLTH-----------------TSPFVG--------------------------------------------------EDNQETYLNISQV--NVDYSEETFSSVS--------------------------------------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT--------------AEICLSHSWL
Activation segment
DFGMSRKIGHAC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMGTPEYLAPE
Binding pocket
KELGRGKFAVVRQYAAKFLEILHEIAVLELAKPRVINLHEVILILEYAAGGEIFSLCLPYLHQNNIVHLDLKPQNILLIVDFGMS
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QF4, Chain A