6QAU Chain A
Serine/threonine-protein kinase ULK2 (ULK2)
Active — 64.0%DFG-inαC-inType1 · 1FV
Resolution
2.48 Å
R-value
0.198
Predicted activity confidence64.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGP
UniProt reference sequence
FEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL
Aligned reference sequence
FEYS--KR------------DLVGHGA----------------FAVVFRGRH--RQK-----------------------------------TDWEVAIKSIN--KKNLSKS---------------------------QILLGKEIKILKEL--------------------------QHENIVALYDVQELPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFLVMEYCNG--------------GDLADYLQA--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRVFLHQIAAAMRILHSK---------------------------------------------GIIHRDL-----KPQNILLSY--ANRRKSSVS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIRIKIADFGFARYLHSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATLCGSPMYMAPEVIMS--------------------------------QHYD-AKADLWSIGTVIYQCLVG-----------------KPPFQA--------------------------------------------------NSPQDLRMFYEKN--RSLMPSIPRETS---------------------------------------------------------------------------------------------------PYLANLLLGLLQRNQKDRMD--------------FEAFFSHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEYS--KR------------DLVGHGA----------------FAVVFRGRH--RQK-----------------------------------TDWEVAIKSIN--KKNLSKS---------------------------QILLGKEIKILKEL--------------------------QHENIVALYDVQELPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFLVMEYCNG--------------GDLADYLQA--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRVFLHQIAAAMRILHSK---------------------------------------------GIIHRDL-----KPQNILLSY--ANRRKSSVS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIRIKIADFGFARYLHSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADLCGSPMYMAPEVIMS--------------------------------QHYD-AKADLWSIGTVIYQCLVG-----------------KPPFQA--------------------------------------------------NSPQDLRMFYEKN--RSLMPSIPRETS---------------------------------------------------------------------------------------------------PYLANLLLGLLQRNQKDRMD--------------FEAFFSHPFL
Activation segment
DFGFARYLHSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADLCGSPMYMAPE
Binding pocket
DLVGHGAFAVVFRVAIKSILLGKEIKILKELQENIVALYDVFLVMEYCNGGDLADYLQAILHSKGIIHRDLKPQNILLIADFGFA
Ligand info
Orthosteric ligand
1FV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QAU, Chain A