6QAT Chain A
Serine/threonine-protein kinase ULK2 (ULK2)
Inactive — 6.4%DFG-inαC-inType1 · FE7
Resolution
2.77 Å
R-value
0.22
Predicted activity confidence6.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANVSGIRIKIADFGFARYLHSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQG
UniProt reference sequence
FEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL
Aligned reference sequence
FEYS--KR------------DLVGHGA----------------FAVVFRGRH--RQK-----------------------------------TDWEVAIKSIN--KKNLSKS---------------------------QILLGKEIKILKEL--------------------------QHENIVALYDVQELPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFLVMEYCNG--------------GDLADYLQA--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRVFLHQIAAAMRILHSK---------------------------------------------GIIHRDL-----KPQNILLSY--ANRRKSSVS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIRIKIADFGFARYLHSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATLCGSPMYMAPEVIMS--------------------------------QHYD-AKADLWSIGTVIYQCLVG-----------------KPPFQA--------------------------------------------------NSPQDLRMFYEKN--RSLMPSIPRETS---------------------------------------------------------------------------------------------------PYLANLLLGLLQRNQKDRMD--------------FEAFFSHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEYS--KR------------DLVGHGA----------------FAVVFRGRH--RQK-----------------------------------TDWEVAIKSIN--KKNLSKS---------------------------QILLGKEIKILKEL--------------------------QHENIVALYDVQELPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFLVMEYCNG--------------GDLADYLQA--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRVFLHQIAAAMRILHSK---------------------------------------------GIIHRDL-----KPQNILLSY--AN-----VS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIRIKIADFGFARYLH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPMYMAPEVIMS--------------------------------QHYD-AKADLWSIGTVIYQCLVG-----------------KPPFQA--------------------------------------------------NSPQDLRMFYEKN--RSLMPSIPRETS---------------------------------------------------------------------------------------------------PYLANLLLGLLQRNQKDRMD--------------FEAFFSHPFL
Activation segment
DFGFARYLH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPMYMAPE
Binding pocket
DLVGHGAFAVVFRVAIKSILLGKEIKILKELQENIVALYDVFLVMEYCNGGDLADYLQAILHSKGIIHRDLKPQNILLIADFGFA
Ligand info
Orthosteric ligand
FE7
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QAT, Chain A