6QAS Chain B
Serine/threonine-protein kinase ULK1 (ULK1)
Active — 99.9%DFG-inαC-inType1,Allosteric · 34W
Resolution
1.75 Å
R-value
0.171
Predicted activity confidence99.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAALCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDA
UniProt reference sequence
FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
Aligned reference sequence
FEFS--RK------------DLIGHGA----------------FAVVFKGRH--REK-----------------------------------HDLEVAVKCIN--KKNLAKS---------------------------QTLLGKEIKILKEL--------------------------KHENIVALYDFQEMAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYLVMEYCNG--------------GDLADYLHA--MR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHSK---------------------------------------------GIIHRDL-----KPQNILLSN--PAGRRANPN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRVKIADFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATLCGSPMYMAPEVIMS--------------------------------QHYD-GKADLWSIGTIVYQCLTG-----------------KAPFQA--------------------------------------------------SSPQDLRLFYEKN--KTLVPTIPRETS---------------------------------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD--------------FDEFFHHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFS--RK------------DLIGHGA----------------FAVVFKGRH--RAA-----------------------------------HDLEVAVKCIN--KKNLAKS---------------------------QTLLGKEIKILKEL--------------------------KHENIVALYDFQEMAN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYLVMEYCNG--------------GDLADYLHA--MR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHSK---------------------------------------------GIIHRDL-----KPQNILLSN--PAGRRANPN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRVKIADFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LCGSPMYMAPEVIMS--------------------------------QHYD-GKADLWSIGTIVYQCLTG-----------------KAPFQA--------------------------------------------------SSPQDLRLFYEKN--KTLVPTIPRETS---------------------------------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD--------------FDEFFHHPFL
Activation segment
DFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LCGSPMYMAPE
Binding pocket
DLIGHGAFAVVFKVAVKCILLGKEIKILKELKENIVALYDFYLVMEYCNGGDLADYLHALLHSKGIIHRDLKPQNILLIADFGFA
Ligand info
Orthosteric ligand
34W
Allosteric ligand
34W
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QAS, Chain B