6QAH Chain A
Mitogen-activated protein kinase 1 (MAPK1)
Active — 99.9%DFG-inαC-inAllosteric,Allosteric · HVB
Resolution
1.58 Å
R-value
0.182
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PEMVRGQVFDVGPRYTNLSYIGEGAGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFLPKEKLKELIFEETARFQPG
UniProt reference sequence
YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
Aligned reference sequence
YTNL----------------SYIGEGA----------------YGMVCSAYD--NV------------------------------------NKVRVAIKKIS--PFEHQTY---------------------------CQRTLREIKILLRF--------------------------RHENIIGINDIIRAPT--IEQMK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYIVQDLME---------------TDLYKLLKT--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA---------------------------------------------NVLHRDL-----KPSNLLLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TCDLKICDFGLARVADPDHDH--TGFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPEIMLN--S-----------------------------KGYT-KSIDIWSVGCILAEMLSN-----------------RPIFPG--------------------------------------------------KHYLDQLNHILGI--LGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD-----------------------------------------------------------------------SKALDLLDKMLTFNPHKRIE--------------VEQALAHPYL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTNL----------------SYIGEGA-----------------GMVCSAYD--NV------------------------------------NKVRVAIKKIS--PFEHQTY---------------------------CQRTLREIKILLRF--------------------------RHENIIGINDIIRAPT--IEQMK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYIVQDLME---------------TDLYKLLKT--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLSNDHICYFLYQILRGLKYIHSA---------------------------------------------NVLHRDL-----KPSNLLLNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-DLKICDFGLARVADPDHDH--TGFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPEIMLN--S-----------------------------KGYT-KSIDIWSVGCILAEMLSN-----------------RPIFPG--------------------------------------------------KHYLDQLNHILGI--LGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD-----------------------------------------------------------------------SKALDLLDKMLTFNPHKRIE--------------VEQALAHPYL
Activation segment
DFGLARVADPDHDH--TGFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPE
Binding pocket
SYIGEGA_GMVCSVAIKKIRTLREIKILLRFRENIIGINDIYIVQDLME_TDLYKLLKTYIHSANVLHRDLKPSNLLLICDFGLA
Ligand info
Orthosteric ligand
HVB
Allosteric ligand
HVB
Ligand typeAllosteric,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6QAH, Chain A