6Q49 Chain A
Cyclin-dependent kinase 2 (CDK2)
Inactive — 0.1%DFG-inαC-out
Resolution
1.0 Å
R-value
0.176
Predicted activity confidence0.1%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
UniProt reference sequence
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Aligned reference sequence
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR--LDTETEGV--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAFGVPVRT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FQKV----------------EKIGEGT----------------YGVVYKARN--KL------------------------------------TGEVVALKKIR--L------V--------------------------PSTAIREISLLKEL--------------------------NHPNIVKLLDVIHTEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLYLVFEFLH---------------QDLKKFMDA--SALT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH---------------------------------------------RVLHRDL-----KPQNLLINT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAIKLADFGLARAFGVPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVVTLWYRAPEILLG--C-----------------------------KYYS-TAVDIWSLGCIFAEMVTR-----------------RALFPG--------------------------------------------------DSEIDQLFRIFRT--LGTPDEVVWPGVTSMPDYKP-SFPKWARQDFSKVVPPLD------------------------------------------------------------------------EDGRSLLSQMLHYDPNKRIS--------------AKAALAHPFF
Activation segment
DFGLARAFGVPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVVTLWYRAPE
Binding pocket
EKIGEGTYGVVYKVALKKITAIREISLLKELNPNIVKLLDVYLVFEFLH_QDLKKFMDAFCHSHRVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
HGQ
Ligand typeAllosteric
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6Q49, Chain A