6PME Chain A
High affinity nerve growth factor receptor (NTRK1)
Inactive — 0.8%DFG-outαC-inType1 · OOY
Resolution
3.0 Å
R-value
0.259
Predicted activity confidence0.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ACVHHIKRRDIVLKWELGEGAFGKVFLAECHNKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYTDYYRVTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP
UniProt reference sequence
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA
Aligned reference sequence
IVLK----------------WELGEGA----------------FGKVFLAEC--HNLLPEQ-------------------------------DKMLVAVKALK--EASESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPDAKLLAGGEDVAPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFGMSRDIYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRTMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------WELGEGA----------------FGKVFLAEC--HN-------------------------------------KMLVAVKALK--EASESA----------------------------RQDFQREAELLTML--------------------------QHQHIVRFFGVCTEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLMVFEYMRH--------------GDLNRFLRS--HGPD------------G----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGLGQLLAVASQVAAGMVYLAGL---------------------------------------------HFVHRDL-----ATRNCLVGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVKIGDFGMSRDIY-TDYY--RV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMLPIRWMPPESILY--------------------------------RKFT-TESDVWSFGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNTEAIDCITQG--RELERPRACP-----------------------------------------------------------------------------------------------------PEVYAIMRGCWQREPQQRHS--------------IKDVHARLQA
Activation segment
DFGMSRDIY-TDYY--RV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMLPIRWMPPE
Binding pocket
WELGEGAFGKVFLVAVKALDFQREAELLTMLQQHIVRFFGVLMVFEYMRHGDLNRFLRSYLAGLHFVHRDLATRNCLVIGDFGMS
Ligand info
Orthosteric ligand
OOY
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6PME, Chain A