6PDJ Chain A
Tyrosine-protein kinase Lck (LCK)
Inactive — 37.2%DFG-outαC-outType1.5_Front · ODJ
Resolution
1.81 Å
R-value
0.169
Predicted activity confidence37.2%
Structure info
Alternate conformationA
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
GHMQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNETAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTA
UniProt reference sequence
LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED
Aligned reference sequence
LKLV----------------ERLGAGQ----------------FGEVWMGYY--N-------------------------------------GHTKVAVKSLK--QGSMS-----------------------------PDAFLAEANLMKQL--------------------------QHQRLVRLYAVVTQE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYMEN--------------GSLVDFLKT--PSGI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTINKLLDMAAQIAEGMAFIEER---------------------------------------------NYIHRDL-----RAANILVSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSCKIADFGLARLIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINY--------------------------------GTFT-IKSDVWSFGILLTEIVTH--G--------------RIPYPG--------------------------------------------------MTNPEVIQNLERG--YRMVRPDNCP-----------------------------------------------------------------------------------------------------EELYQLMRLCWKERPEDRPT--------------FDYLRSVLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLV----------------ERLGAGQ----------------FGEVWMGYY--N-------------------------------------GHTKVAVKSLK--QGSMS-----------------------------PDAFLAEANLMKQL--------------------------QHQRLVRLYAVVTQE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYMEN--------------GSLVDFLKT--PSGI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTINKLLDMAAQIAEGMAFIEER---------------------------------------------NYIHRDL-----RAANILVSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSCKIADFGLARLIEDNE-T--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPEAINY--------------------------------GTFT-IKSDVWSFGILLTEIVTH--G--------------RIPYPG--------------------------------------------------MTNPEVIQNLERG--YRMVRPDNCP-----------------------------------------------------------------------------------------------------EELYQLMRLCWKERPEDRPT--------------FDYLRSVLED
Activation segment
DFGLARLIEDNE-T--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGAKFPIKWTAPE
Binding pocket
ERLGAGQFGEVWMVAVKSLAFLAEANLMKQLQQRLVRLYAVYIITEYMENGSLVDFLKTFIEERNYIHRDLRAANILVIADFGLA
Ligand info
Orthosteric ligand
ODJ
Allosteric ligand
CXS
Ligand typeType1.5_Front
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6PDJ, Chain A