6P8E Chain B
Cyclin-dependent kinase 4 (CDK4)
Inactive — 0.1%DFG-inαC-out
Resolution
2.3 Å
R-value
0.175
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues9
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSEIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE
UniProt reference sequence
YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
Aligned reference sequence
YEPV----------------AEIGVGA----------------YGTVYKARD--PH------------------------------------SGHFVALKSVR--VPNGGGGGGGL-----------------------PISTVREVALLRRL--EAF---------------------EHPNVVRLMDVCATSR--TDREI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVTLVFEHVD---------------QDLRTYLDK--APPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAETIKDLMRQFLRGLDFLHAN---------------------------------------------CIVHRDL-----KPENILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTVKLADFGLARIYSYQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPVVVTLWYRAPEVLLQ--------------------------------STYA-TPVDMWSVGCIFAEMFRR-----------------KPLFCG--------------------------------------------------NSEADQLGKIFDL--IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEME---------------------------------------------------------------------------ESGAQLLLEMLTFNPHKRIS--------------AFRALQHSYL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
--------------------------------------------GTVYKARD--PH------------------------------------SGHFVALKSVR--VPN---GEEGL-----------------------PISTVREVALLRRL--EAF---------------------EHPNVVRLMDVCATS------EI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVTLVFEHVD---------------QDLRTYLDK--APPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPAETIKDLMRQFLRGLDFLHAN---------------------------------------------CIVHRDL-----KPENILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGTVKLADFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRAPEVLLQ--------------------------------STYA-TPVDMWSVGCIFAEMFRR-----------------KPLFCG--------------------------------------------------NSEADQLGKIFDL--IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEME---------------------------------------------------------------------------ESGAQLLLEMLTFNPHKRIS--------------AFRALQHSYL
Activation segment
DFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRAPE
Binding pocket
________GTVYKVALKSVSTVREVALLRRLEPNVVRLMDVTLVFEHVD_QDLRTYLDKFLHANCIVHRDLKPENILVLADFGL_
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6P8E, Chain B