6P5S Chain A
Homeodomain-interacting protein kinase 2 (HIPK2)
Active — 61.2%DFG-inαC-inType1 · 3NG
Resolution
2.19 Å
R-value
0.2
Predicted activity confidence61.2%
Structure info
Alternate conformationB
Missing atoms27
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QLVQHEVLCSMTNTYEVLEFLGRGQVVKCWKRGTNEIVAIKILRQGQIEVSILARLSTESADDYNFVRAYECFQHHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVTLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDF
UniProt reference sequence
YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV
Aligned reference sequence
YEVL----------------EFLGRGT----------------FGQVVKCWK--RG------------------------------------TNEIVAIKILK--NHPSY-----------------------------ARQGQIEVSILARL--STESA-------------------DDYNFVRAYECFQHKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTCLVFEMLE---------------QNLYDFLKQ--NKFS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPLKYIRPVLQQVATALMKLKSL---------------------------------------------GLIHADL-----KPENIMLVD--PSRQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYRVKVIDFGSASHVSKAVC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STYLQSRYYRAPEIILG--------------------------------LPFC-EAIDMWSLGCVIAELFLG-----------------WPLYPG--------------------------------------------------ASEYDQIRYISQT--QGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADR------------------------------REFIDLLKKMLTIDADKRIT--------------PIETLNHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEVL----------------EFLGR-------------------GQVVKCWK--RG------------------------------------TNEIVAIKIL--------------------------------------RQGQIEVSILARL--STESA-------------------DDYNFVRAYECFQH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTCLVFEMLE---------------QNLYDFLKQ--NKFS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPLKYIRPVLQQVATALMKLKSL---------------------------------------------GLIHADL-----KPENIMLVD--PSRQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYRVKVIDFGSASHV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLQSRYYRAPEIILG--------------------------------LPFC-EAIDMWSLGCVIAELFLG-----------------WPLYPG--------------------------------------------------ASEYDQIRYISQT--QGLPAEYLLSAGTKTTRFFNRDTD-PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADR------------------------------REFIDLLKKMLTIDADKRIT--------------PIETLNHPFV
Activation segment
DFGSASHV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLQSRYYRAPE
Binding pocket
EFLGR___GQVVKVAIKILQGQIEVSILARLSYNFVRAYECCLVFEMLE_QNLYDFLKQKLKSLGLIHADLKPENIMLVIDFGSA
Ligand info
Orthosteric ligand
3NG
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6P5S, Chain A