6OKO Chain A
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Inactive — 0.0%DFG-outαC-inType2 · 1FN
Resolution
2.1 Å
R-value
0.181
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms4
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLS
UniProt reference sequence
LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE
Aligned reference sequence
LENQ----------------ELVGKGG----------------FGTVFRAQH--RK------------------------------------WGYDVAVKIVN------------------------------------SKAISREVKAMASL--------------------------DNEFVLRLEGVIEKVN--WDQDP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPALVTKFMEN--------------GSLSGLLQS--QC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLKEVVLGMFYLHDQ--NP-----------------------------------------VLLHRDL-----KPSNVLLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHVKLADFGLSTFQGGSQSG--TGS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPGGTLGYLAPELFVN--VN----------------------------RKAS-TASDVYSFGILMWAVLAG-------------------------REVELP------------------------------------------TEPSLVYEAVCNR--QNRPSLAELPQAGPETPGL--------------------------------------------------------------------------------------------EGLKELMQLCWSSEPKDRPS--------------FQECLPKTDE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKKL----------------EFVGKGG----------------FGVVFRAHH--RT------------------------------------WNHDVAVKIVN------------------------------------SKKISWEVKAMVNL--------------------------RNENVLLLLGVTEDLQ--WDFVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQALVTRFMEN--------------GSLAGLLQP--EA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRPWPLLCRLLQEVVLGMCYLHSL--DP-----------------------------------------PLLHRDL-----KPSNILLDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELHAKLADF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLAYLDPELLFK--VN----------------------------LKAS-KASDVYSFGILVWAVLAG-------------------------REAEL------------------------------------------------------VD--QSRPPLTELPPGSPETPGL--------------------------------------------------------------------------------------------EKLKELMIHCWGSQSENRPS--------------FQDCEPKTNE
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTLAYLDPE
Binding pocket
EFVGKGGFGVVFRVAVKIVKISWEVKAMVNLRENVLLLLGVALVTRFMENGSLAGLLQPHSLDPPLLHRDLKPSNILLLADF___
Ligand info
Orthosteric ligand
1FN
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6OKO, Chain A