6O9L Chain 8
Cyclin-dependent kinase 7 (CDK7)
Active — 97.7%DFG-inαC-in
Resolution
0.0 Å
R-value
999.0
Predicted activity confidence97.7%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPN
UniProt reference sequence
YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
Aligned reference sequence
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--LGHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
-EKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--LGHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Activation segment
DFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPE
Binding pocket
DFLGEGQFATVYKVAIKKITALREIKLLQELSPNIIGLLDASLVFDFME_TDLEVIIKDYLHQHWILHRDLKPNNLLLLADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6O9L, Chain 8