6O9D Chain A
Interleukin-1 receptor-associated kinase 4 (IRAK4)
Active — 91.4%DFG-inαC-inType1 · LTY
Resolution
2.51 Å
R-value
0.197
Predicted activity confidence91.4%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQVMRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT
UniProt reference sequence
NVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE
Aligned reference sequence
NVT---NNFDERPISVGG--NKMGEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA--AMVDITTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARASEKFAQT--VMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
NVT---NNFDERPISVGG--NKMGEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA-------TTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARAS-----Q--VM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Activation segment
DFGLARAS-----Q--VM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIVGTTAYMAPE
Binding pocket
NKMGEGGFGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA
Ligand info
Orthosteric ligand
LTY
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6O9D, Chain A