6O8B Chain B
Serine/threonine-protein kinase TBK1 (TBK1)
Inactive — 2.6%DFG-inαC-inType1 · BX7
Resolution
3.4 Å
R-value
0.244
Predicted activity confidence2.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLDTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDQAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNEL
UniProt reference sequence
HLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSD
Aligned reference sequence
HLWL--LS------------DILGQGA----------------TANVFRGRH--KK------------------------------------TGDLFAIKVFN--NISFLRP---------------------------VDVQMREFEVLKKL--------------------------NHKNIVKLFAIEEETT--TR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKVLIMEFCPC--------------GSLYTVLEE--PSNAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPESEFLIVLRDVVGGMNHLREN---------------------------------------------GIVHRDI-----KPGNIMRVI--GEDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVYKLTDFGAARELEDDEQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLYGTEEYLHPDMYER--AVLRKDHQ----------------------KKYG-ATVDLWSIGVTFYHAATG-----------------SLPFRP--FEGPR-------------------------------------------RNKEVMYKIITGK--PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ------------------------------------------------------------------------------VLLTPVLANILEADQEKCWG--------------FDQFFAETSD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
HLWL--LS------------DILGQGA----------------TANVFRGRH--KK------------------------------------TGDLFAIKVFN--NISFLRP---------------------------VDVQMREFEVLKKL--------------------------NHKNIVKLFAIEEETT--TR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKVLIMEFCPC--------------GSLYTVLEE--PSNAY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPESEFLIVLRDVVGGMNHLREN---------------------------------------------GIVHRNI-----KPGNIMRVI--GEDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSVYKLTDFGAARELEDDEQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VELYGTEEYLHPDMYER--AVLRKDHQ----------------------KKYG-ATVDLWSIGVTFYHAATG-----------------SLPFRP--FEGPR-------------------------------------------RNKEVMYKIITGK--PSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ------------------------------------------------------------------------------VLLTPVLANILEADQEKCWG--------------FDQFFAETSD
Activation segment
DFGAARELEDDEQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VELYGTEEYLHPD
Binding pocket
DILGQGATANVFRFAIKVFVQMREFEVLKKLNKNIVKLFAIVLIMEFCPCGSLYTVLEPHLRENGIVHRNIKPGNIMRLTDFGAA
Ligand info
Orthosteric ligand
BX7
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6O8B, Chain B