6O5Z Chain B
Mixed lineage kinase domain-like protein (MLKL)
Inactive — 29.1%DFG-outαC-inType2 · LN4
Resolution
2.285 Å
R-value
0.188
Predicted activity confidence29.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLS
UniProt reference sequence
LSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST
Aligned reference sequence
LSGS--PW------------ILLRENE----------------VSTLYKGEY----------------------------------------HRAPVAIKVFK--KLQAGSIAIV------------------------RQTFNKEIKTMKKF--------------------------ESPNILRIFGICIDET--VTPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFSIVMEYCEL--------------GTLRELLDR--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTLGKRMVLVLGAARGLYRLHHS--EA-----------------------------------------PELHGKI-----RSSNFLVTQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYQVKLAGFELRKTQTSMSLG--TTREK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDRVKSTAYLSPQELED--VF----------------------------YQYD-VKSEIYSFGIVLWEIATG-----------------DIPFQG--------------------------------------------------CNSEKIRKLVAVK--RQQEPLGEDCP----------------------------------------------------------------------------------------------------SELREIIDECRAHDPSVRPS--------------VDEILKKLST
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSGS--PW------------ILLRENE----------------VSTLYKGEY----------------------------------------HRAPVAIKVFK--K------AIV------------------------RQTFNKEIKTMKKF--------------------------ESPNILRIFGICIDET--VTPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFSIVMEYCEL--------------GTLRELLDR--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTLGKRMVLVLGAARGLYRLHHS--EA-----------------------------------------PELHGKI-----RSSNFLVTQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYQVKLAGF--------------TTREK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDRVKSTAYLSPQELED--VF----------------------------YQYD-VKSEIYSFGIVLWEIATG-----------------DIPFQG--------------------------------------------------CNSEKIRKLVAVK--RQQEPLGEDCP----------------------------------------------------------------------------------------------------SELREIIDECRAHDPSVRPS--------------VDEILKKLS-
Activation segment
GF--------------TTREK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDRVKSTAYLSPQ
Binding pocket
ILLRENEVSTLYKVAIKVFTFNKEIKTMKKFEPNILRIFGISIVMEYCELGTLRELLDRHHSEAPELHGKIRSSNFLVLAGF___
Ligand info
Orthosteric ligand
LN4
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6O5Z, Chain B