6NJA Chain A
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Active — 92.2%DFG-inαC-inType1 · ADE
Resolution
1.92 Å
R-value
0.188
Predicted activity confidence92.2%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GPLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVEEDSVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR
UniProt reference sequence
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
Aligned reference sequence
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKVGPGYLGSGGSRNSSSLDHPDER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDVYEEDSY--VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKV--------------------ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDV-EEDS---VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Activation segment
DFGLSRDV-EEDS---VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIE
Binding pocket
KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS
Ligand info
Orthosteric ligand
ADE
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6NJA, Chain A