6NG0 Chain A
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)
Inactive — 0.0%DFG-inαC-outType1 · B49
Resolution
2.05 Å
R-value
0.202
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms4
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PDIFNRDPRDHYDLLQRLGGGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISALARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGD
UniProt reference sequence
YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV
Aligned reference sequence
YDLL----------------QRLGGGT----------------YGEVFKARD--KV------------------------------------SGDLVALKMVK--MEPDDD----------------------------VSTLQKEILILKTC--------------------------RHANIVAYHGSYLWLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGA--------------GSLQDIYQV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSELQISYVCREVLQGLAYLHSQ---------------------------------------------KKIHRDI-----KGANILIND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGEVRLADFGISAQIGATLAR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSFIGTPYWMAPEVAAV--ALK---------------------------GGYN-ELCDIWSLGITAIELAEL-----------------QPPLFD--------------------------------------------------VHPLRVLFLMTKS--GYQPPRLKEKGKWS-------------------------------------------------------------------------------------------------AAFHNFIKVTLTKSPKKRPS--------------ATKMLSHQLV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDLL----------------QRLGG-------------------GEVFKARD--KV------------------------------------SGDLVALKMVK--MEPDDD----------------------------VSTLQKEILILKTC--------------------------RHANIVAYHGSYLWLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWICMEFCGA--------------GSLQDIYQV--TG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSELQISYVCREVLQGLAYLHSQ---------------------------------------------KKIHRDI-----KGANILIND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGEVRLADFGISA-----LAR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEFIGTPYWMAPEVAAV--ALK---------------------------GGYN-ELCDIWSLGITAIELAEL-----------------QPPLFD--------------------------------------------------VHPLRVLFLMTKS--GYQPPRLKEKGKWS-------------------------------------------------------------------------------------------------AAFHNFIKVTLTKSPKKRPS--------------ATKMLSHQLV
Activation segment
DFGISA-----LAR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEFIGTPYWMAPE
Binding pocket
QRLGG___GEVFKVALKMVTLQKEILILKTCRANIVAYHGSWICMEFCGAGSLQDIYQVYLHSQKKIHRDIKGANILILADFGIS
Ligand info
Orthosteric ligand
B49
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6NG0, Chain A