6NFI Chain A
Tyrosine-protein kinase BTK (BTK)
Inactive — 0.0%DFG-outαC-inType1 · KLP
Resolution
2.41 Å
R-value
0.22
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues6
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
YGSWEIDPKDLTFLKELGTVVKYGKWRGQYDVAIKMISMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
UniProt reference sequence
LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILD
Aligned reference sequence
LTFL----------------KELGTGQ----------------FGVVKYGKW--R-------------------------------------GQYDVAIKMIK--EGSMS-----------------------------EDEFIEEAKVMMNL--------------------------SHEKLVQLYGVCTKQR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIFIITEYMAN--------------GCLLNYLRE--MRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFQTQQLLEMCKDVCEAMEYLESK---------------------------------------------QFLHRDL-----AARNCLVND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGVVKVSDFGLSRYVLDDEYT--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSKFPVRWSPPEVLMY--------------------------------SKFS-SKSDIWAFGVLMWEIYSL--G--------------KMPYER--------------------------------------------------FTNSETAEHIAQG--LRLYRPHLAS-----------------------------------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT--------------FKILLSNILD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTFL----------------KELGT--------------------VVKYGKW--R-------------------------------------GQYDVAIKMI-----SMS-----------------------------EDEFIEEAKVMMNL--------------------------SHEKLVQLYGVCTKQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFIITEYMAN--------------GCLLNYLRE--MRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFQTQQLLEMCKDVCEAMEYLESK---------------------------------------------QFLHRDL-----AARNCLVND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGVVKVSDFG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFPVRWSPPEVLMY--------------------------------SKFS-SKSDIWAFGVLMWEIYSL--G--------------KMPYER--------------------------------------------------FTNSETAEHIAQG--LRLYRPHLAS-----------------------------------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT--------------FKILLSNILD
Activation segment
DFG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFPVRWSPPE
Binding pocket
KELGT____VVKYVAIKMIEFIEEAKVMMNLSEKLVQLYGVFIITEYMANGCLLNYLREYLESKQFLHRDLAARNCLVVSDFG__
Ligand info
Orthosteric ligand
KLP
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6NFI, Chain A