6NE7 Chain A
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Active — 93.2%DFG-outαC-inATPlike · AMP
Resolution
1.99 Å
R-value
0.206
Predicted activity confidence93.2%
Structure info
Alternate conformationC
Missing atoms3
Missing residues4
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GPLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYASLRGFLRESRKVGERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVEEDSVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR
UniProt reference sequence
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
Aligned reference sequence
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKVGPGYLGSGGSRNSSSLDHPDER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDVYEEDSY--VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------ASLRGFLRE--SRKVG-------------------ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDV-EEDS---VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Activation segment
DFGLSRDV-EEDS---VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIE
Binding pocket
KTLGEGEFGKVVKVAVKMLD_LSEFNVLKQVNPHV_KLYGALLIVEYAKYASLRGFLREYLAEMKL_HRDLAARNILVISDFGL_
Ligand info
Orthosteric ligand
AMP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6NE7, Chain A