6N79 Chain A
Tyrosine-protein kinase JAK1 (JAK1)
Active — 95.6%DFG-inαC-inType1 · KES
Resolution
2.27 Å
R-value
0.227
Predicted activity confidence95.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPNHIADLKKEIEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIEKETVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
UniProt reference sequence
LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINK
Aligned reference sequence
LVQG----------------EHLGRGT----------------RTHIYSGTL--MDYKDDEGTSEE--------------------------KKIKVILKVLD--PSHRDI----------------------------SLAFFEAASMMRQV--------------------------SHKHIVYLYGVCVRDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVEEFVEG--------------GPLDLFMHR--KSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTTPWKFKVAKQLASALSYLEDK---------------------------------------------DLVHGNV-----CTKNLLLAR--EGIDSEC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPFIKLSDPGIPITVLSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QECIERIPWIAPECVED--S-----------------------------KNLS-VAADKWSFGTTLWEICYN--G--------------EIPLKD--------------------------------------------------KTLIEKERFYESR--CRPVTPSC-------------------------------------------------------------------------------------------------------KELADLMTRCMNYDPNQRPF--------------FRAIMRDINK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKRI----------------RDLGEG-------------------HFGKVEL--CRY-DPEGTGE------------------------------QVAVKSLK--PNHIAD----------------------------LKKEIE---ILRNL--------------------------YHENIVKYKGICTEGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLIM--EFLPS--------------GSLKEYLPK--NKN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KINLKQQLKYAVQICKGMDYLGSR---------------------------------------------QYVH------------RDLAA--RNVLVES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHQVKIGDFGLTKAIEKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVKDDRVFWYAPECLMQ--S-----------------------------K-FY-IASDVWSFGVTLHEYCDS--D--------------SSPLKV--------------------------------------------------NTLKEGKR--------LPCPPNC-------------------------------------------------------------------------------------------------------PEVYQLMRKCWEFQPSNRTS--------------FIEGFEALLK
Activation segment
DFGLTKAIEKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVKDDRVFWYAPE
Binding pocket
RDLGEGHFGKVELVAVKSLDLKKEIEILRNLYENIVKYKGIKLIMEFLPSGSLKEYLPKYLGSRQYVHRDLAARNVLVIGDFGLT
Ligand info
Orthosteric ligand
KES
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6N79, Chain A