6N3O Chain A
eIF-2-alpha kinase GCN2 (EIF2AK4)
Inactive — 0.0%DFG-inαC-outType1.5_Back · KA7
Resolution
2.4 Å
R-value
0.202
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues18
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIENAVHYLYIQMEYCEASTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVKIGDFGLATDHLAFSEALYVSPEYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPP
UniProt reference sequence
VHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
Aligned reference sequence
VHKG----------------KCIGSDE--QL------------GKLVYNALE--TA------------------------------------TGGFVLLYEWV--LQWQKKMGPFLTSQEKEKIDKCKKQ---------IQGTETEFNSLVKL--------------------------SHPNVVRYLAMNLKEQ--DDSI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVDILVEHISG--------------VSLAAHLSH--SG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPVHQLRRYTAQLLSGLDYLHSN---------------------------------------------SVVHKVL-----SASNVLVDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGTVKITDYSISKRLADICKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFEQTRVRFSDNALP---------------------------------YKTG-KKGDVWRLGLLLLSLSQG-------------------------QECG-----------------------------------------------------------EYPVTIPSDLP----------------------------------------------------------------------------------------------------ADFQDFLKKCVCLDDKERWS--------------PQQLLKHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
SRYF----------------IEFEELQ--LL------------GKGAFGA----------------------------------------------------V--IKVQNKLDGCCYAVKRIPINPASRQ---------FRRIKGEVTLLSRL--------------------------HHENIVRY--YNAWIE--NAVH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYIQMEYCEA--------------STLRDTIDQ--GL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRDTVRLWRLFREILDGLAYIHEK---------------------------------------------GMIHRNL-----KPVNIFLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDHVKIGDLAFSEALEYNQKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLFSLGIIFFEMSYHP---------------------------------MVT--ASERIFVLNQLRDPTS-------------------------------------------------------------------------------------------------PKFP----------------------------------------------------------------------------------------------------EDFDDAKQKSVNHDPAKRPT--------------ATELLKLPPP
Activation segment
DLAFSEALEYNQKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLFSLGIIFFEMS
Binding pocket
QLLGKGAFGAVIKYAVKRIRIKGEVTLLSRLHENIVRYYNA__________________YIHEKGMIHRNLKPVNIFLIGDFGLA
Ligand info
Orthosteric ligand
KA7
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6N3O, Chain A