6N3N Chain A
eIF-2-alpha kinase GCN2 (EIF2AK4)
Inactive — 0.5%DFG-inαC-outType1 · KA4
Resolution
3.01 Å
R-value
0.219
Predicted activity confidence0.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues18
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASFRRIKGEVTLLSRLHHENIVRYYNAWIENVHYLYIQMEYCEASTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRNLKPVNIFLDSDDHVKIGDFGLATDHLAFEALYVSPEYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDHAKQKSVISWLLNHDPAKRPTATELLKSELLPP
UniProt reference sequence
VHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFI
Aligned reference sequence
VHKG----------------KCIGSDE--QL------------GKLVYNALE--TA------------------------------------TGGFVLLYEWV--LQWQKKMGPFLTSQEKEKIDKCKKQ---------IQGTETEFNSLVKL--------------------------SHPNVVRYLAMNLKEQ--DDSI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVDILVEHISG--------------VSLAAHLSH--SG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPVHQLRRYTAQLLSGLDYLHSN---------------------------------------------SVVHKVL-----SASNVLVDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGTVKITDYSISKRLADICKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFEQTRVRFSDNALP---------------------------------YKTG-KKGDVWRLGLLLLSLSQG-------------------------QECG-----------------------------------------------------------EYPVTIPSDLP----------------------------------------------------------------------------------------------------ADFQDFLKKCVCLDDKERWS--------------PQQLLKHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
SRYF----------------IEFEELQ--LL------------GKGAFGA----------------------------------------------------V--IKVQNKLDGCCYAVKRIPINPASFR---------IKG---EVTLLSRL--------------------------HHENIVRY---YNAWI--ENVH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYIQMEYCEA--------------STLRDTIDQ--GL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRDTVRLWRLFREILDGLAYIHEK---------------------------------------------GMIHRNL-----KPVNIFLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDHVKIGD----FGLA--TDH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAFEALYVSPEYN-----------------------------------------QKVDLFSLGIIFFEMSLN-------------------------QLRD-----------------------------------------------------------PTSPKFPED-H----------------------------------------------------------------------------------------------------AKQKSVISWLLNHDPAKRPT--------------ATELLKLLPP
Activation segment
D----FGLA--TDH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAFEALYVSPEYN
Binding pocket
QLLGKGAFGAVIKYAVKRIRIKGEVTLLSRLHENIVRYYNA__________________YIHEKGMIHRNLKPVNIFLIGDFGLA
Ligand info
Orthosteric ligand
KA4
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6N3N, Chain A