6MWE Chain A
Angiopoietin-1 receptor (TEK)
Inactive — 0.2%DFG-outαC-inType2 · 919
Resolution
2.05 Å
R-value
0.149
Predicted activity confidence0.2%
Structure info
Alternate conformationA
Missing atoms25
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEE
UniProt reference sequence
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
Aligned reference sequence
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRMK--EYASKDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVYVKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRM------------------------------------------GELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVY--K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Activation segment
DFGLSRGQEVY--K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIE
Binding pocket
DVIGEGNFGQVLKAAIKRM___GELEVLCKLGPNIINLLGAYLAIEYAPHGNLLDFLRKYLSQKQFIHRDLAARNILVIADFGLS
Ligand info
Orthosteric ligand
919
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6MWE, Chain A