6MNH Chain A
Serine/threonine-protein kinase ULK1 (ULK1)
Inactive — 4.0%DFG-inαC-inType1 · JVD
Resolution
1.73 Å
R-value
0.19
Predicted activity confidence4.0%
Structure info
Alternate conformationB
Missing atoms8
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNSIRVKIADFGFARYLTLGSPMYMAPEVIMAQHYDGKADLWSIGTIVYQCLTGKAPFQAASPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPV
UniProt reference sequence
FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
Aligned reference sequence
FEFS--RK------------DLIGHGA----------------FAVVFKGRH--REK-----------------------------------HDLEVAVKCIN--KKNLAKS---------------------------QTLLGKEIKILKEL--------------------------KHENIVALYDFQEMAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYLVMEYCNG--------------GDLADYLHA--MR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHSK---------------------------------------------GIIHRDL-----KPQNILLSN--PAGRRANPN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRVKIADFGFARYLQSNMMA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATLCGSPMYMAPEVIMS--------------------------------QHYD-GKADLWSIGTIVYQCLTG-----------------KAPFQA--------------------------------------------------SSPQDLRLFYEKN--KTLVPTIPRETS---------------------------------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD--------------FDEFFHHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFS--RK------------DLIGHGA----------------FAVVFKGRH--REK-----------------------------------HDLEVAVKCIN--KKNLAKS---------------------------QTLLGKEIKILKEL--------------------------KHENIVALYDFQEMAN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYLVMEYCNG--------------GDLADYLHA--MR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSEDTIRLFLQQIAGAMRLLHSK---------------------------------------------GIIHRDL-----KPQNILLS-----------N---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRVKIADFGFARYL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TL-GSPMYMAPEVIMA--------------------------------QHYD-GKADLWSIGTIVYQCLTG-----------------KAPFQA--------------------------------------------------ASPQDLRLFYEKN--KTLVPTIPRETS---------------------------------------------------------------------------------------------------APLRQLLLALLQRNHKDRMD--------------FDEFFHHPFL
Activation segment
DFGFARYL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TL-GSPMYMAPE
Binding pocket
DLIGHGAFAVVFKVAVKCILLGKEIKILKELKENIVALYDFYLVMEYCNGGDLADYLHALLHSKGIIHRDLKPQNILLIADFGFA
Ligand info
Orthosteric ligand
JVD
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6MNH, Chain A