6MM6 Chain E
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Active — 85.7%DFG-inαC-in
Resolution
2.39 Å
R-value
0.225
Predicted activity confidence85.7%
Structure info
Alternate conformationA
Missing atoms5
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFEEEIRVINEKCGKEFTEF
UniProt reference sequence
FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF
Aligned reference sequence
FERI----------------KTLGTGS----------------FGRVMLVKH--KE------------------------------------TGNHYAMKILD--KQKVVKLKQ-------------------------IEHTLNEKRILQAV--------------------------NFPFLVKLEFSFKDNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLYMVMEYVPG--------------GEMFSHLRR--IG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFSEPHARFYAAQIVLTFEYLHSL---------------------------------------------DLIYRDL-----KPENLLIDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGYIQVTDFGFAKRVKGRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WTLCGTPEYLAPEIILS--------------------------------KGYN-KAVDWWALGVLIYEMAAG-----------------YPPFFA--------------------------------------------------DQPIQIYEKIVSG--KVRFPSHFS------------------------------------------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFG--NLKNG-------VNDIKNHKWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDRI----------------KTLGTGS----------------FGRVMLVKH--KE------------------------------------SGNHYAMKILD--KQKVVKLKQ-------------------------IEHTLNEKRILQAV--------------------------NFPFLVKLEFSFKDNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLYMVMEYVAG--------------GEMFSHLRR--IG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFSEPHARFYAAQIVLTFEYLHSL---------------------------------------------DLIYRDL-----KPENLLIDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGYIQVTDFGFAKRVKGRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W-LCGTPEYLAPEIILS--------------------------------KGYN-KAVDWWALGVLIYEMAAG-----------------YPPFFA--------------------------------------------------DQPIQIYEKIVSG--KVRFPSHFS------------------------------------------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFG--NLKNG-------VNDIKNHKWF
Activation segment
DFGFAKRVKGRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W-LCGTPEYLAPE
Binding pocket
KTLGTGSFGRVMLYAMKILHTLNEKRILQAVNPFLVKLEFSYMVMEYVAGGEMFSHLRRYLHSLDLIYRDLKPENLLIVTDFGFA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6MM6, Chain E