6LVM Chain A
Fibroblast growth factor receptor 3 (FGFR3)
Active — 99.2%DFG-inαC-inType1.5_Back · EVR
Resolution
2.53 Å
R-value
0.211
Predicted activity confidence99.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDSEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT
UniProt reference sequence
LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR
Aligned reference sequence
LTLG----------------KPLGEGC----------------FGQVVMAEA--IGIDKDRAA-----------------------------KPVTVAVKMLK--DDATDKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVLVEYAAK--------------GNLREFLRA--RRPPGLDYSFDTCKPPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLTFKDLVSCAYQVARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDVHNLDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLG----------------KPLGEGC----------------FGQVVMAEA--IGIDKDRAA-----------------------------KPVTVAVKMLK--DDATDKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVLVEYAAK--------------GNLREFLRA--RRPPGLD---------SE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLTFKDLVSCAYQVARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDVHNLD----KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLARDVHNLD----KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPE
Binding pocket
KPLGEGCFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVLVEYAAKGNLREFLRAYLASQKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
EVR
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6LVM, Chain A