6L20 Chain G
Casein kinase II subunit alpha' (CSNK2A2)
Active — 100.0%DFG-inαC-inType1 · E3U
Resolution
3.09 Å
R-value
0.249
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGEVFEAINITNNERVVVKILKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ
UniProt reference sequence
YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF
Aligned reference sequence
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNERVVVKILK--PVK-------------------------------KKKIKREVKILENL--R-----------------------GGTNIIKLIDTVKDPV--SK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEYINN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILTDFDIRFYMYELLKALDYCHSK---------------------------------------------GIMHRDV-----KPHNVMIDH--Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKKLRLIDWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--R--------------EPFFHG--------------------------------------------------QDNYDQLVRIAKV--LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-----------------------------------------------------------------PEALDLLDKLLRYDHQQRLT--------------AKEAMEHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLV----------------RKLGRG-------------------EVFEAIN--IT------------------------------------NNERVVVKIL-----K-------------------------------KKKIKREVKILENL--R-----------------------GGTNIIKLIDTVKDPV--SK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEYINN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILTDFDIRFYMYELLKALDYCHSK---------------------------------------------GIMHRDV-----KPHNVMIDH--Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKKLRLIDWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--R--------------EPFFHG--------------------------------------------------QDNYDQLVRIAKV--LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-----------------------------------------------------------------PEALDLLDKLLRYDHQQRLT--------------AKEAMEHPYF
Activation segment
DWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPE
Binding pocket
RKLGRG___EVFEVVVKILKIKREVKILENLRTNIIKLIDTALVFEYIN_NTDFKQLYQYCHSKGIMHRDVKPHNVMILIDWGLA
Ligand info
Orthosteric ligand
E3U
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6L20, Chain G