6KZC Chain A
NT-3 growth factor receptor (NTRK3)
Inactive — 0.2%DFG-outαC-inType2 · DZC
Resolution
2.0 Å
R-value
0.19
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms12
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRVYSTDYYRLHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDI
UniProt reference sequence
IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHA
Aligned reference sequence
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLSPTK-------------------------------DKMLVAVKALK--DPTLAA----------------------------RKDFQREAELLTNL--------------------------QHEHIVKFYGVCGDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAMILVDGQPRQAKG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELGLSQMLHIASQIASGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSRDVYSTDYY--RLFNPSGNDFCIWCEVG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSFGVILWEIFTY--G--------------KQPWFQ--------------------------------------------------LSNTEVIECITQG--RVLERPRVCP-----------------------------------------------------------------------------------------------------KEVYDVMLGCWQREPQQRLN--------------IKEIYKILHA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLSPTK-------------------------------DKMLVAVKALK--DPTLAA----------------------------RKDFQREAELLTNL--------------------------QHEHIVKFYGVCGDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDA------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELGLSQMLHIASQIASGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSR-VYSTDYY--RL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSFGVILWEIFTY--G--------------KQPWFQ--------------------------------------------------LSNTEVIECITQG--RVLERPRVCP-----------------------------------------------------------------------------------------------------KEVYDVMLGCWQREPQQRLN--------------IKEIYKILHA
Activation segment
DFGMSR-VYSTDYY--RL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTMLPIRWMPPE
Binding pocket
RELGEGAFGKVFLVAVKALDFQREAELLTNLQEHIVKFYGVIMVFEYMKHGDLNKFLRAYLASQHFVHRDLATRNCLVIGDFGMS
Ligand info
Orthosteric ligand
DZC
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6KZC, Chain A