6KYR Chain B
Serine/threonine-protein kinase DCLK1 (DCLK1)
Active — 99.6%DFG-inαC-in
Resolution
2.206 Å
R-value
0.182
Predicted activity confidence99.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
FQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFTAAGVSVIATTALDKERQVFRRR
UniProt reference sequence
YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV
Aligned reference sequence
YKVG----------------RTIGDGN----------------FAVVKECVE--RS------------------------------------TAREYALKIIK--KSKCRGK---------------------------EHMIQNEVSILRRV--------------------------KHPNIVLLIEEMDVPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYLVMELVKG--------------GDLFDAITS--TN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYTERDASGMLYNLASAIKYLHSL---------------------------------------------NIVHRDI-----KPENLLVYE--HQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSLKLGDFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPEIIAE--------------------------------TGYG-LKVDIWAAGVITYILLCG-----------------FPPFRG--SG----------------------------------------------DDQEVLFDQILMG--QVDFPSPYWDNVS--------------------------------------------------------------------------------------------------DSAKELITMMLLVDVDQRFS--------------AVQVLEHPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YKVG----------------RTIGDGN----------------FAVVKECVE--RS------------------------------------TAREYALKIIK--KSKCRGK---------------------------EHMIQNEVSILRRV--------------------------KHPNIVLLIEEMDVPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYLVMELVKG--------------GDLFDAITS--TN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYTERDASGMLYNLASAIKYLHSL---------------------------------------------NIVHRDI-----KPENLLVYE--HQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSLKLGDFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPEIIAE--------------------------------TGYG-LKVDIWAAGVITYILLCG-----------------FPPFRG---------------------------------------------------DQEVLFDQILMG--QVDFPSPYWDNVS--------------------------------------------------------------------------------------------------DSAKELITMMLLVDVDQRFS--------------AVQVLEHPWV
Activation segment
DFGLATIVDGPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTVCGTPTYVAPE
Binding pocket
RTIGDGNFAVVKEYALKIIMIQNEVSILRRVKPNIVLLIEEYLVMELVKGGDLFDAITSYLHSLNIVHRDIKPENLLVLGDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6KYR, Chain B