6KMH Chain B
Peripheral plasma membrane protein CASK (CASK)
Active — 99.1%DFG-inαC-out
Resolution
2.4 Å
R-value
0.19
Predicted activity confidence99.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNS
UniProt reference sequence
YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL
Aligned reference sequence
YELC----------------EVIGKGP----------------FSVVRRCIN--RE------------------------------------TGQQFAVKIVD--VAKFTSSPGLS-----------------------TEDLKREASICHML--------------------------KHPHIVELLETYSSDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYMVFEFMDG--------------ADLCFEIVK--RADAGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYSEAVASHYMRQILEALRYCHDN---------------------------------------------NIIHRDV-----KPHCVLLAS--KEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAPVKLGGFGVAIQLGESGLV--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGRVGTPHFMAPEVVKR--------------------------------EPYG-KPVDVWGCGVILFILLSG-----------------CLPFYG---------------------------------------------------TKERLFEGIIKG--KYKMNPRQWSHIS--------------------------------------------------------------------------------------------------ESAKDLVRRMLMLDPAERIT--------------VYEALNHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YELC----------------EVIGKGP----------------FSVVRRCIN--RE------------------------------------TGQQFAVKIVD--VAKFTSSPGLS-----------------------TEDLKREASICHML--------------------------KHPHIVELLETYSSDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYMVFEFMDG--------------ADLCFEIVK--RADAGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYSEAVASHYMRQILEALRYCHDN---------------------------------------------NIIHRDV-----KPHCVLLAS--KEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAPVKLGGFGVAIQLGESGLV--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGRVGTPHFMAPEVVKR--------------------------------EPYG-KPVDVWGCGVILFILLSG-----------------CLPFYG---------------------------------------------------TKERLFEGIIKG--KYKMNPRQWSHIS--------------------------------------------------------------------------------------------------ESAKDLVRRMLMLDPAERIT--------------VYEALNHPWL
Activation segment
GFGVAIQLGESGLV--A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGRVGTPHFMAPE
Binding pocket
EVIGKGPFSVVRRFAVKIVDLKREASICHMLKPHIVELLETYMVFEFMDGADLCFEIVKYCHDNNIIHRDVKPHCVLLLGGFGVA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6KMH, Chain B