6K0J Chain A
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)
Inactive — 49.4%DFG-inαC-inType1 · CQO
Resolution
2.35 Å
R-value
0.175
Predicted activity confidence49.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNNKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDAKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRAA
UniProt reference sequence
YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
Aligned reference sequence
YEVL----------------KVIGKGS----------------FGQVVKAYD--HK------------------------------------VHQHVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--RKQDKD------------------NTMNVIHMLENFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMTFELLS---------------MNLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSLPLVRKFAHSILQCLDALHKN---------------------------------------------RIIHCDL-----KPENILLKQ--QG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGIKVIDFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTYIQSRFYRAPEVILG--------------------------------ARYG-MPIDMWSLGCILAELLTG-----------------YPLLPG--------------------------------------------------EDEGDQLACMIEL--LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD-------------------------------------------PLFLDFLKQCLEWDPAVRMT--------------PGQALRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEVL----------------KVIGKGS----------------FGQVVKAYD--HK------------------------------------VHQHVALKMVR--NNKRF-----------------------------HRQAAEEIRILEHL--RKQDKD------------------NTMNVIHMLENFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMTFELLS---------------MNLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSLPLVRKFAHSILQCLDALHKN---------------------------------------------RIIHCDA-----KPENILLKQ--QG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGIKVIDFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YT-IQSRFYRAPEVILG--------------------------------ARYG-MPIDMWSLGCILAELLTG-----------------YPLLPG--------------------------------------------------EDEGDQLACMIEL--LGMPSQKLLDASKRAKNFV-SKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD-------------------------------------------PLFLDFLKQCLEWDPAVRMT--------------PGQALRHPWL
Activation segment
DFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YT-IQSRFYRAPE
Binding pocket
KVIGKGSFGQVVKVALKMVQAAEEIRILEHLRMNVIHMLENCMTFELLS_MNLYELIKKALHKNRIIHCDAKPENILLVIDFGSS
Ligand info
Orthosteric ligand
CQO
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6K0J, Chain A