6JQR Chain A
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Inactive — 0.4%DFG-outαC-inType1 · C6F
Resolution
2.2 Å
R-value
0.181
Predicted activity confidence0.4%
Structure info
Alternate conformation—
Missing atoms11
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
RYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISVSIQVAVKMLKEDSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAE
UniProt reference sequence
LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGC
Aligned reference sequence
LEFG----------------KVLGSGA----------------FGKVMNATA--YGISKTG-------------------------------VSIQVAVKMLK--EKADSSE---------------------------REALMSELKMMTQL--G-----------------------SHENIVNLLGACTLSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYLIFEYCCY--------------GDLLNYLRS--KREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTFEDLLCFAYQVAKGMEFLEFK---------------------------------------------SCVHRDL-----AARNVLVTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKVVKICDFGLARDIMSDSNY--VVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESLFE--------------------------------GIYT-IKSDVWSYGILLWEIFSL--G--------------VNPYPG--I-----------------------------------------------PVDANFYKLIQNG--FKMDQPFYAT-----------------------------------------------------------------------------------------------------EEIYIIMQSCWAFDSRKRPS--------------FPNLTSFLGC
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEFG----------------KVLGSGA----------------FGKVMNATA--YGIS----------------------------------VSIQVAVKMLK--E--DSSE---------------------------REALMSELKMMTQL--G-----------------------SHENIVNLLGACTLSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYLIFEYCCY--------------GDLLNYLRS--KREKF---------------------------------------------------------------------SN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTFEDLLCFAYQVAKGMEFLEFK---------------------------------------------SCVHRDL-----AARNVLVTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKVVKICDF------MSDSNY--VVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESLFE--------------------------------GIYT-IKSDVWSYGILLWEIFSL--G--------------VNPYPG--I-----------------------------------------------PVDANFYKLIQNG--FKMDQPFYAT-----------------------------------------------------------------------------------------------------EEIYIIMQSCWAFDSRKRPS--------------FPNLTSFLGC
Activation segment
DF------MSDSNY--VVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPE
Binding pocket
KVLGSGAFGKVMNVAVKMLALMSELKMMTQLGENIVNLLGAYLIFEYCCYGDLLNYLRSFLEFKSCVHRDLAARNVLVICDF___
Ligand info
Orthosteric ligand
C6F
Allosteric ligand
CXS
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6JQR, Chain A