6JOI Chain A
Platelet-derived growth factor receptor alpha (PDGFRA)
Inactive — 0.0%DFG-inαC-outType1 · 6T2
Resolution
3.1 Å
R-value
0.224
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms6
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIIIEYCFYGDLVNYLHKNRDSFLGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSD
UniProt reference sequence
LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN
Aligned reference sequence
LVLG----------------RVLGSGA----------------FGKVVEGTA--YGLSRSQ-------------------------------PVMKVAVKMLK--PTARSSE---------------------------KQALMSELKIMTHL--G-----------------------PHLNIVNLLGACTKSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIITEYCFY--------------GDLVNYLHK--NRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTLLDLLSFTYQVARGMEFLASK---------------------------------------------NCVHRDL-----AARNVLLAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIVKICDFGLARDIMHDSNY--VSK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSTFLPVKWMAPESIFD--------------------------------NLYT-TLSDVWSYGILLWEIFSL--G--------------GTPYPG--M-----------------------------------------------MVDSTFYNKIKSG--YRMAKPDHAT-----------------------------------------------------------------------------------------------------SEVYEIMVKCWNSEPEKRPS--------------FYHLSEIVEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------RVLGSGA----------------FGKVVEGTA--YGLSRSQ-------------------------------PVMKVAVKMLK--PTARSSE---------------------------KQALMSELKIMTHL--G-----------------------PHLNIVNLLGACTKSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIIIEYCFY--------------GDLVNYLHK--NRDSFL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTLLDLLSFTYQVARGMEFLASK---------------------------------------------NCVHRDL-----AARNVLLAQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIVKICDFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFLPVKWMAPESIFD--------------------------------NLYT-TLSDVWSYGILLWEIFSL--G--------------GTPYPG--M-----------------------------------------------MVDSTFYNKIKSG--YRMAKPDHAT-----------------------------------------------------------------------------------------------------SEVYEIMVKCWNSEPEKRPS--------------FYHLSEIVEN
Activation segment
DFGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFLPVKWMAPE
Binding pocket
RVLGSGAFGKVVEVAVKMLALMSELKIMTHLGLNIVNLLGAYIIIEYCFYGDLVNYLHKFLASKNCVHRDLAARNVLLICDFGL_
Ligand info
Orthosteric ligand
6T2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6JOI, Chain A