6JMF Chain A
Tyrosine-protein kinase Fes/Fps (FES)
Inactive — 33.0%DFG-inαC-inType1 · 9FC
Resolution
2.0 Å
R-value
0.199
Predicted activity confidence33.0%
Structure info
Alternate conformation—
Missing atoms3
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRH
UniProt reference sequence
LVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQS
Aligned reference sequence
LVLG----------------EQIGRGN----------------FGEVFSGRL--RA------------------------------------DNTLVAVKSCR--ETLPPDL---------------------------KAKFLQEARILKQY--------------------------SHPNIVRLIGVCTQKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMELVQG--------------GDFLTFLRT--EGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRVKTLLQMVGDAAAGMEYLESK---------------------------------------------CCIHRDL-----AARNCLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVLKISDFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPEALNY--------------------------------GRYS-SESDVWSFGILLWETFSL--G--------------ASPYPN--------------------------------------------------LSNQQTREFVEKG--GRLPCPELCP-----------------------------------------------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS--------------FSTIYQELQS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------EQIGRGN----------------FGEVFSGRL--RA------------------------------------DNTLVAVKSCR--ETLPPDL---------------------------KAKFLQEARILKQY--------------------------SHPNIVRLIGVCTQKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMELVQG--------------GDFLTFLRT--EGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLRVKTLLQMVGDAAAGMEYLESK---------------------------------------------CCIHRDL-----AARNCLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNVLKISDFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPEALNY--------------------------------GRYS-SESDVWSFGILLWETFSL--G--------------ASPYPN--------------------------------------------------LSNQQTREFVEKG--GRLPCPELCP-----------------------------------------------------------------------------------------------------DAVFRLMEQCWAYEPGQRPS--------------FSTIYQELQS
Activation segment
DFGMSREEADGVYA--ASG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRQVPVKWTAPE
Binding pocket
EQIGRGNFGEVFSVAVKSCKFLQEARILKQYSPNIVRLIGVYIVMELVQGGDFLTFLRTYLESKCCIHRDLAARNCLVISDFGMS
Ligand info
Orthosteric ligand
9FC
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6JMF, Chain A