6IN0 Chain A
Ephrin type-A receptor 3 (EPHA3)
Inactive — 37.9%DFG-inαC-inType3,Allosteric · O4B
Resolution
1.5 Å
R-value
0.197
Predicted activity confidence37.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
AKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSSNLLL
UniProt reference sequence
ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDK
Aligned reference sequence
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGKIPIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ISID----------------KVVGAGE----------------FGEVCSGRL--KLPSK---------------------------------KEISVAIKTLK--VGYTEKQ---------------------------RRDFLGEASIMGQF--------------------------DHPNIIRLEGVVTKSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVTEYMEN--------------GSLDSFLRK--HDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMKYLSDM---------------------------------------------GYVHRDL-----AARNILINS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTSPEAIAY--------------------------------RKFT-SASDVWSYGIVLWEVMSY--G--------------ERPYWE--------------------------------------------------MSNQDVIKAVDEG--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK--------------FEQIVSILDK
Activation segment
DFGLSRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPIRWTSPE
Binding pocket
KVVGAGEFGEVCSVAIKTLDFLGEASIMGQFDPNIIRLEGVMIVTEYMENGSLDSFLRKYLSDMGYVHRDLAARNILIVSDFGLS
Ligand info
Orthosteric ligand
O4B
Allosteric ligand
O4B
Ligand typeType3,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6IN0, Chain A