6IB2 Chain A
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Inactive — 0.2%DFG-inαC-inType1.5_Front · 862
Resolution
2.1 Å
R-value
0.224
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms20
Missing residues8
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
QTGYLTIGGQRYQAEINDLENLGEMGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFAYMAPERIDRADVWSLGISLVELATGQFPYKKCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKT
UniProt reference sequence
LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
Aligned reference sequence
LENL----------------GEMGSGT----------------CGQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDFGISGRLVDSKAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSAGCAAYMAPERIDP--PDPTK-------------------------PDYD-IRADVWSLGISLVELATG-----------------QFPYKN--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LENL----------------GEM---------------------GQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AYMAPERID---------------------------------------RADVWSLGISLVELATG-----------------QFPYKK--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Activation segment
DF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AYMAPE
Binding pocket
GEMG_____QVWKIAVKQMRILMDLDVVLKSHPYIVQCFGTFIAMELMGTCAEKLKKRMLKEKHGVIHRDVKPSNILLLCDF___
Ligand info
Orthosteric ligand
862
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6IB2, Chain A