6I99 Chain A
Cytoplasmic tyrosine-protein kinase BMX (BMX)
Inactive — 24.8%DFG-outαC-outType1 · H88
Resolution
2.0 Å
R-value
0.234
Predicted activity confidence24.8%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LYFQGELKREEITLLKELGSGQFGVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLRE
UniProt reference sequence
ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEP
Aligned reference sequence
ITLL----------------KELGSGQ----------------FGVVQLGKW--K-------------------------------------GQYDVAVKMIK--EGSMS-----------------------------EDEFFQEAQTMMKL--------------------------SHPKLVKFYGVCSKEY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYISN--------------GCLLNYLRS--HGK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLEPSQLLEMCYDVCEGMAFLESH---------------------------------------------QFIHRDL-----AARNCLVDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCVKVSDFGMTRYVLDDQYV--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTKFPVKWSAPEVFHY--------------------------------FKYS-SKSDVWAFGILMWEVFSL--G--------------KQPYDL--------------------------------------------------YDNSQVVLKVSQG--HRLYRPHLAS-----------------------------------------------------------------------------------------------------DTIYQIMYSCWHELPEKRPT--------------FQQLLSSIEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------KELGSGQ----------------FGVVKLGKW--K-------------------------------------GQYDVAVKMIK--EGSMS-----------------------------EDEFFQEAQTMMKL--------------------------SHPKLVKFYGVCSKEY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYISN--------------GCLLNYLRS--HGK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLEPSQLLEMCYDVCEGMAFLESH---------------------------------------------QFIHRDL-----AARNCLVDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCVKVSDFGMTRYVLDDQYV--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTKFPVKWSAPEVFHY--------------------------------FKYS-SKSDVWAFGILMWEVFSL--G--------------KMPYDL--------------------------------------------------YTNSEVVLKVSQG--HRLYRPHLAS-----------------------------------------------------------------------------------------------------DTIYQIMYSCWHELPEKRPT--------------FQQLLSSIEP
Activation segment
DFGMTRYVLDDQYV--SS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTKFPVKWSAPE
Binding pocket
KELGSGQFGVVKLVAVKMIEFFQEAQTMMKLSPKLVKFYGVYIVTEYISNGCLLNYLRSFLESHQFIHRDLAARNCLVVSDFGMT
Ligand info
Orthosteric ligand
H88
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6I99, Chain A