6HZV Chain C
Tyrosine-protein kinase JAK3 (JAK3)
Inactive — 44.6%DFG-inαC-inType1 · GYW
Resolution
2.46 Å
R-value
0.224
Predicted activity confidence44.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQGPDQQRDFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDVVSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML
UniProt reference sequence
LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNS
Aligned reference sequence
LEWH----------------ENLGHGS----------------FTKIYRGCR--HEVVDGEA------------------------------RKTEVLLKVMD--AKHKNC----------------------------MESFLEAASLMSQV--------------------------SYRHLVLLHGVCMAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSTMVQEFVHL--------------GAIDMYLRK--RGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPASWKLQVVKQLAYALNYLEDK---------------------------------------------GLPHGNV-----SARKVLLAR--EGADGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPFIKLSDPGVSPAVLSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMLTDRIPWVAPECLRE--A-----------------------------QTLS-LEADKWGFGATVWEVFSG--V--------------TMPISA--------------------------------------------------LDPAKKLQFYEDR--QQLPAPKW-------------------------------------------------------------------------------------------------------TELALLIQQCMAYEPVQRPS--------------FRAVIRDLNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKYI----------------SQLGKGN----------------F-GSVELCR-----YDPLG------------------------------DNTGALVAVKQ--LQGPDQ----------------------------QRDFLKALHSDFIV--------------------------KYR------GV--SY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLRLVMEYLPS--------------GCLRDFLQR--HRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDASRLLLYSSQICKGMEYLGSR---------------------------------------------RCVHRDL-----AARNILVES--EIADGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKLLPLDKDVVSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFWYAPESL-S--D-----------------------------NIFS-RQSDVWSFGVVLYELFSA--E--------------FLRMPA--------------------------------------------------L--SRLLELLEEG--QRLPAPCP-------------------------------------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS--------------FSALGPQLDM
Activation segment
KDVVSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFWYAPE
Binding pocket
SQLGKGNFGSVELVAVKQLDFQREIQILKALHDFIVKYRGVRLVMEYLPSGCLRDFLQRYLGSRRCVHRDLAARNILVIADFGLA
Ligand info
Orthosteric ligand
GYW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6HZV, Chain C