6HXF Chain A
Serine/threonine-protein kinase 10 (STK10)
Inactive — 0.0%DFG-inαC-inType1 · R70
Resolution
2.09 Å
R-value
0.192
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms13
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKLQFIGTPYWMAPEVVMCEMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAE
UniProt reference sequence
WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
Aligned reference sequence
WEIV----------------GELGDGA----------------FGKVYKAKN--KE------------------------------------TGALAAAKVIE--TKSEEE----------------------------LEDYIVEIEILATC--------------------------DHPYIVKLLGAYYHDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIMIEFCPG--------------GAVDAIMLE--LDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK---------------------------------------------RIIHRDL-----KAGNVLMTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGDIRLADFGVSAKNLKTLQK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETMKD-------------------------TPYD-YKADIWSLGITLIEMAQI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--DPPTLLTPSKWS---------------------------------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS--------------AAQLLEHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEIV----------------GELGDGA----------------FGKVYKAKN--KE------------------------------------TGALAAAKVIE--T--EEE----------------------------LEDYIVEIEILATC--------------------------DHPYIVKLLGAYYHDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIMIEFCPG--------------GAVDAIMLE--LDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK---------------------------------------------RIIHRDL-----KAGNVLMTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGDIRLADFGVSAKNLK-LQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIGTPYWMAPEVVMC--E-MKD-------------------------TPYD-YKADIWSLGITLIEMAQI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--DPPTLLTPSKWS---------------------------------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS--------------AAQLLEHPFV
Activation segment
DFGVSAKNLK-LQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIGTPYWMAPE
Binding pocket
GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFGVS
Ligand info
Orthosteric ligand
R70
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6HXF, Chain A