6HES Chain A
Ephrin type-A receptor 2 (EPHA2)
Inactive — 0.0%DFG-outαC-out
Resolution
1.13 Å
R-value
0.181
Predicted activity confidence0.0%
Structure info
Alternate conformationC
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLP
UniProt reference sequence
VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDK
Aligned reference sequence
VTRQ----------------KVIGAGE----------------FGEVYKGML--KTSSGK--------------------------------KEVPVAIKTLK--AGYTEKQ---------------------------RVDFLGEAGIMGQF--------------------------SHHNIIRLEGVISKYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMMIITEYMEN--------------GALDKFLRE--KDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSVLQLVGMLRGIAAGMKYLANM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPEA--TYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGGKIPIRWTAPEAISY--------------------------------RKFT-SASDVWSFGIVMWEVMTY--G--------------ERPYWE--------------------------------------------------LSNHEVMKAINDG--FRLPTPMDCP-----------------------------------------------------------------------------------------------------SAIYQLMMQCWQQERARRPK--------------FADIVSILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VTRQ----------------KVIGAGE----------------FGEVYKGML-------K--------------------------------KEVPVAIKTLK--AGYTEKQ---------------------------RVDFLGEAGIMGQF--------------------------SHHNIIRLEGVISKYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMMIITEYMEN--------------GALDKFLRE--KDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSVLQLVGMLRGIAAGMKYLANM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPEAISY--------------------------------RKFT-SASDVWSFGIVMWEVMTY--G--------------ERPYWE--------------------------------------------------LSNHEVMKAINDG--FRLPTPMDCP-----------------------------------------------------------------------------------------------------SAIYQLMMQCWQQERARRPK--------------FADIVSILDK
Activation segment
DFGLS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPE
Binding pocket
KVIGAGEFGEVYKVAIKTLDFLGEAGIMGQFSHNIIRLEGVMIITEYMENGALDKFLREYLANMNYVHRDLAARN_LVVSDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6HES, Chain A