6HBN Chain B
Casein kinase II subunit alpha (CSNK2A1)
Active — 100.0%DFG-inαC-inType1 · FXB
Resolution
1.59 Å
R-value
0.188
Predicted activity confidence100.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMG
UniProt reference sequence
YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
Aligned reference sequence
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNEKVVVKILK--PVK-------------------------------KKKIKREIKILENL--R-----------------------GGPNIITLADIVKDPV--SR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEHVNN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTDYDIRFYMYEILKALDYCHSM---------------------------------------------GIMHRDV-----KPHNVMIDH--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRKLRLIDWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--K--------------EPFFHG--------------------------------------------------HDNYDQLVRIAKV--LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS-----------------------------------------------------------------PEALDFLDKLLRYDHQSRLT--------------AREAMEHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNEKVVVKILK--PVK-------------------------------KKKIKREIKILENL--R-----------------------GGPNIITLADIVKDPV--SR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEHVNN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLTDYDIRFYMYEILKALDYCHSM---------------------------------------------GIMHRDV-----KPHNVMIDH--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRKLRLIDWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--K--------------EPFFHG--------------------------------------------------HDNYDQLVRIAKV--LGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVS-----------------------------------------------------------------PEALDFLDKLLRYDHQSRLT--------------AREAMEHPYF
Activation segment
DWGLAEFYHPGQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPE
Binding pocket
RKLGRGKYSEVFEVVVKILKIKREIKILENLRPNIITLADIALVFEHVN_NTDFKQ__LYCHSMGIMHRDVKPHNVMILIDWGLA
Ligand info
Orthosteric ligand
FXB
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6HBN, Chain B